Influenza Vaccine Dose-Response in Infants and Toddlers: Immunogenicity and Reactogenicity

Exclusion Criteria

• •Child has history of laboratory-confirmed influenza
• •Child has history of any prior influenza immunization
• •Child has history of anaphylactic reaction to any component of the vaccine (i.e. egg)
• •Child has received immune globulin or other blood products within the prior six weeks
• •Child has received injected or oral steroids within the prior six weeks (inhaled or topical steroids allowed)
• •Child has a bleeding diathesis or condition associated with prolonged bleeding time that would contraindicate intramuscular injection (thrombocytopenia, coagulation disorder, anti-coagulant therapy)
• •Child is or will be enrolled in any other clinical trial of a drug, vaccine or medical device during the study period
• •Child is scheduled to receive a live vaccine (notably measles, mumps, rubella or varicella vaccines) during the study period
• •Child has a health condition which, in the opinion of the investigator, would interfere with the evaluation or pose a health risk to the child