Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Austin Health
The investigators hypothesise:
1. In patients with SIRS and oliguria the early administration of sodium bicarbonate or sodium chloride (control) triggered by an abnormally high NGAL level is feasible.
2. In patients with SIRS and oliguria the early administration of sodium bicarbonate or sodium chloride (control) triggered by an abnormally high NGAL level is safe.
3. In patients with SIRS and oliguria the early administration of sodium bicarbonate or sodium chloride (control) triggered by an abnormally high NGAL level leads to signs or trends of efficacy as measured by serum creatinine derived indices.
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Consent obtained
Diagnosis of SIRS. Requires any TWO of:
temperature \> 38°C or \< 36°C OR heart rate \> 90 beats/min OR respiratory rate \> 20 breaths/min. PaCO2 \< 32 mm Hg OR alteration of white blood cell count \> 12,000 cells/mm3, \< 4,000 cells/mm3, or the presence of \> 10% immature neutrophils
elevated lipocalin level
Arterial line already in place
Central venous catheter already in place
Age ≥ 18 years
Within 24 hours of admission to the ICU
You may not be if
Unlikely to remain in ICU for \>72 hours
Moribund patient
Pre-existing CKD, transplant or ESRD
Receiving (or about to receive) continuous renal replacement therapy for acute renal failure at time of enrolment
Diagnosis of acute GN, AIN, vasculitis or post-renal aetiology
Known/suspected study allergy to sodium bicarbonate
Enrolling physician concern about patient enrolment
