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A Multiple Dose, Randomized, Double-Blind (3rd Party Open), Placebo-Controlled Phase 1 Study To Evaluate The Pharmacokinetics And Safety Of CP-945598 In Subjects With Nonalcoholic Steatohepatitis (NASH)
CP-945598 is a potent and selective Cannabinoid-1 (CB1) receptor antagonist currently being developed for the treatment of obesity. CP-945598 is also being considered as a potential treatment for non-alcoholic steatohepatitis (NASH). This study will investigate the steady-state safety, toleration and pharmacokinetics of multiple oral dose administration of CP-945598. Results will be used to estimate the pharmacokinetic characteristics in NASH patients and underwrite the safety of this compound prior to any further studies in NASH patients.
Age
18 - 65 years
Sex
ALL
Healthy Volunteers
No
Pfizer Investigational Site
Anaheim, California, United States
Pfizer Investigational Site
Anaheim, California, United States
Pfizer Investigational Site
Durham, North Carolina, United States
Start Date
July 1, 2008
Primary Completion Date
November 1, 2008
Completion Date
November 1, 2008
Last Updated
August 13, 2009
9
ACTUAL participants
Active treatment
DRUG
Placebo
DRUG
Lead Sponsor
Pfizer
Data Source & Attribution
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