Known or suspected allergy to tolterodine ER or darifenacin or their components

Subjects with irregular day and night patterns such as night shift workers

Significant medical problems know to affect heart rate (ie., hypertension, hypotension, history of heart failure, history of pulmonary disease, etc.)

Medication with potential known to affect heart rate

History of any malignancy within the past 5 years, with the exception of localized basal cell carcinoma of the skin

Pregnant or nursing women

Subjects with diseases such as urinary retention, gastric retention, uncontrolled narrow-angle glaucoma, severe renal insufficiency, etc.

Pharmacologic Effects of Darifenacin and Tolterodine on Cardiovascular Parameters in Healthy Subjects