About Pricing FAQs Blog

Loading clinical trials...

Your health journey, clearly organized.

Find Clinical Trials →

Legal

Privacy Policy
Terms of Service

© 2026 Clareo Health. All rights reserved.

Using Beta Blockers to Treat Mitral Regurgitation | Clinical Trials | Clareo Health

Back to clinical trial search

TERMINATEDPhase 1NCT00700947

Using Beta Blockers to Treat Mitral Regurgitation

The purpose of this study tests whether beta-blocker will benefit asymptomatic patients with chronic primary mitral regurgitation.

Lead sponsor: Wake Forest University Health Sciences•1 U.S. locations•View source on ClinicalTrials.gov

Clareo plain-language summary

What this study is about

Generating AI summary...

Save this trial guide to your notes

Keep your clinical trial research organized — questions to ask, what to expect, and key details.

Sponsors

Lead Sponsor

Wake Forest University Health Sciences

The purpose of this study tests 1) whether Toprol xl, a beta-blocker will benefit asymptomatic patients with chronic primary mitral regurgitation; 2) investigate the effects of chronic mitral regurgitation on left ventricular remodeling, left ventricular function,exercise capacity and clinical symptoms.

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•Diagnosis of sever primary mitral regurgitation
•Normal subjects

Exclusion Criteria

•Left ventricle ejection fraction of \<55% pre and post operation
•Pregnancy or Lactation
•Secondary mitral regurgitation due to coronary artery disease, cardiomyopathy, uncontrolled hypertension, or severe aortic stenosis.

Related studies

RECRUITINGPhase 3

Acoramidis Transthyretin Amyloidosis Prevention Trial in the Young (ACT-EARLY) Study in Asymptomatic Carriers of a Pathogenic TTR Variant

NCT06563895 · Amyloidosis, Amyloid Cardiomyopathy, and more

CHoice of OptImal transCatheter trEatment for Mitral Insufficiency Registry

NCT04688190 · Mitral Regurgitation, Mitral Valve Disease, and more

RECRUITINGPhase 2

CAMEO-FONTAN -Dapagliflozin in the Failing Fontan Circulation

NCT06762964 · Fontan Circulation, Single Ventricle Heart Disease, and more

Remote Cardiac Rehab for Adolescents With Congenital Heart Disease

NCT06015191 · Congenital Heart Disease in Children

Association Between Radial Artery Intervention and Development of Neuropathy in the Hand - A Prospective Study

NCT05365282 · Ischemic Heart Disease, Nerve Injury, and more

View all related studies →

Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: August 14, 2018Terms

Trial snapshot

StatusTERMINATED

PhasePHASE1

Enrollment27

Start dateOct 2007

Last updatedAug 14, 2018

Condition

Heart Disease Mitral Regurgitation Heart Valve Disease Mitral Valve Insufficiency

Locations shown

Wake Forest University Baptist Medical Center

Winston-Salem, North Carolina

For caregivers

Use Clareo to keep notes, questions, trial details, and next steps organized before and after appointments.

Start free trial →

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: August 14, 2018Data synced to Clareo: May 17, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions