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Keep this study
Lead
Villa Pineta Hospital
With
University of Modena and Reggio Emilia
This is a single-blind multicentre controlled randomized trial with consecutive recruitment. Randomization list by blocks will be available. Group comparison will be made between active therapies including TPEP added to conventional MABT (Intervention) or MABT alone (Control). Active therapy will last 10 consecutive daily sessions in both groups.
Primary outcome
Efficacy comparison on change in:
a.arterial oxygenation (as assessed by PaO2/FiO2 ratio and/or SatO2 index)
Secondary outcomes
Efficacy comparison on change in:
1. Sputum characteristics
2. Daily sputum volume
3. Perceived sensation
4. Lung functions (as assessed by spirometry and RM strength)
Age
25–85
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
chronic hypersecretion as defined by \> 30 mL/die sputum production (7)
chronic airway obstruction (by definition)
COPD, bronchiectasis, asthma, cystic disease, etc. with or without chronic respiratory failure
adulthood
smoking or non-smoking habit
Peak Cough Expiratory Flow \> 150 L\*min-1 (5)
willingness to participate
You may not be if
childhood
presence of acute exacerbation
severe concomitant cardiovascular diseases
concomitant neoplastic diseases
non compliance/adherence to TPEP
concomitant use of chronic mechanical ventilation
use of amynophyllines and/or any active drugs (e.g. N-Acetyl-Cysteine)
Clareo Health | Efficacy of Temporary Positive Expiratory Pressure (TPEP) in Chronic Hypersecretion
