The Effects of Rasagiline on Cognitive Deficits Associated With Parkinson's Disease

Inclusion Criteria

• •1. Male and female patients of any age
• •2. Diagnosis of Idiopathic PD according to the UK Brain Bank Criteria for the clinical diagnosis of PD.
• •3. Patients with cognitive impairment associated with PD, defined as:
• •1. Subjective complaints of impaired cognitive functions such as forgetfulness, word finding difficulties or inattentiveness
• •2. Presence of objectively demonstrable cognitive deficits in at least 2 out of the 4 cognitive domains typically impaired in PD. These include attention, executive functions, memory and visuo-spatial functions. The performance in the following test scores must be 1.5 standard deviations below the mean normative score for age and education of the patient: Digit Span for attention, Letter Fluency test for executive function, Logical Memory Sub-scale from the Wechsler Memory Scale-Revised and Line Orientation Test for visuo-spatial function.
• •4. Patients with a Hoehn and Yahr stage I-III when "on"
• •5. Literate patients who are able to follow test instructions