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Keep this study
Lead
Oregon Health and Science University
Following an overnight fast, subjects will undergo fMRI measurements of the hypothalamus, brainstem and whole brain during an infusion of either normal saline, pramlintide, leptin, or the combination leptin and pramlintide.
Age
18–45
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
Age 18 year to 45 years of age
MI 18 to 25 kg/m2 or ≥ 30 kg/m2
At maximal lifetime weight
Weight stable for at least 3 months
You may not be if
Those with a major medical illness or who require prescription medication, including: cancer, coronary artery disease, hypertension, and diabetes.
Subjects taking psychiatric or centrally-acting (CNS) medications or who are diagnosed with a psychiatric or neurological illness, including:
* depression
* anorexia
* bulimia
* seizure disorder.
Exercise \> 30 minutes, 3 times a week
Alcohol consumption \> 2 drinks / day
Weight \> 350 lbs (159 kg) (weight limit for MR machine)
Illicit drug use
Pregnancy
Extreme dietary habits as determined by a GCRC nutritionist: very high or low dietary carbohydrate or fat intakes
Those with a contraindication to exposure to strong magnetic fields: presence of metal in the body such as body piercing, shrapnel, cardiac pacemakers or aneurysm clips
Those with claustrophobia
Anaphylaxis and known hypersensitivity to E. coli-derived proteins
Allergies or contraindications to metreleptin or pramlintide
Renal or hepatic impairment
Women who are lactating
Tobacco use
Clareo Health | A Study of the Functional Magnetic Resonance Imaging Response to Leptin and Pramlintide
