Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
University of Chicago
Age
18–65
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Age \> 18 years to \<65 years
Severe persistent asthma (per 2002 National Asthma Education and Prevention Program guidelines)
Treatment with daily fluticasone (500 ug BID) and salmeterol (50 ug BID) during the past 4 or more weeks
Pre-bronchodilator FEV1 \<80% predicted
Post-bronchodilator improvement in FEV1 of at least 12% and 200 mL or a PC20 to methacholine of \<8 mg/mL
Evidence of inadequate asthma control in the past 2 weeks: use of rescue inhaler \> 4 days and \>8 occasions in the past 2 weeks, daytime asthma symptoms \> 4 days in the past 2 weeks, or 1 or more nocturnal awakening in the past 2 weeks
No evidence of alternate diagnosis (e.g., sarcoidosis, eosinophilic pneumonia) on bronchoscopy performed as part of routine care in the Refractory Obstructive Lung Disorders clinic.
You may not be if
Pregnancy or lactation
Severe metabolic disease
Other respiratory or inflammatory disorders (sarcoidosis, emphysema)
Hypokalemia, dehydration
Uncontrolled seizure disorder ( 2 or more seizures in last year)
Major surgery, trauma
Pre-existing liver disease (AST or ALT \>10% above the upper limit of normal)
Elevated CK (\>50% above the upper limit of normal)
History of alcohol abuse
Current smokers or ex-smokers with \> 10 pack-years of smoking
Partial ileal bypass surgery
Concurrent treatment with drugs known to be have potential interactions or associated with rhabdomyolysis (Cimetadine, danazole, delavaridine, diltiazem, fenofiibrate, nefazodone, niacin, protease inhibitors, quinipristoline/dalfopristin, ranolazine, rifampin, telbivudine, telithromycin)
HIV patients taking protease inhibitors
History of allergy or intolerance to statin
Use of 1 or more doses of any cholesterol lowering medication in the previous 12 weeks
Clinical indication for treatment with statins
Clareo Health | Evaluation of Lovastatin in Severe Persistent Asthma
