Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
The Cleveland Clinic
The study population will consist of patients who are scheduled for open laparoscopic or laparoscopic assisted surgery for colon cancer. Patients will randomized into one of two groups. The intervention group will receive combined regional and general anesthesia during surgery. Postoperative pain treatment will be based on regional anesthesia techniques. The Control group will receive general anesthesia during surgery. Postoperative pain treatment will be based primarily on opioids. After surgery, patients will be followed daily during their hospital stay. Patients will be contacted by telephone every 6 months for five years. Quality of life questionnaires will be administered at these follow ups.
Age
18–85
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Primary colon cancer without known extension beyond colon (T3, N0, M0)
Scheduled for open, laparoscopic assisted and laparoscopic resection of the colon.
Written informed consent, including willingness to be randomized to epidural anesthesia/analgesia or to sevoflurane general anesthesia and postoperative opioid analgesia.
You may not be if
Previous surgery for colon cancer;
Any contraindication to epidural anesthesia or analgesia (including coagulopathy, abnormal anatomy);
Any contraindication to midazolam, propofol, sevoflurane, fentanyl, or morphine;
Age \<18 or \>85 years old;
ASA Physical Status ≥4;
Other cancer not believed by the attending surgeon to be in long-term remission;
Systemic disease believed by the attending surgeon or anesthesiologist to present ≥25% two-year mortality.
