PROCHYMAL™ (Human Adult Stem Cells) for the Treatment of Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD)

Exclusion Criteria

• •Participant has been diagnosed with asthma or other clinically relevant lung disease other than COPD (e.g. restrictive lung diseases, sarcoidosis, tuberculosis, idiopathic pulmonary fibrosis, bronchiectasis, or lung cancer).
• •Participant has been diagnosed with α1-antitrypsin deficiency.
• •Participant has a body mass greater than 150 kg (330 lb) or less than 40 kg (88 lb).
• •Participant has active infection.
• •Participant has had a significant exacerbation of COPD or has required mechanical ventilation within 4 weeks of screening.
• •The participant with clinically relevant uncontrolled medical condition not associated with COPD.
• •Participant has documented history of uncontrolled heart failure.
• •Participant has pulmonary hypertension due to left heart condition.
• •Participant has atrial fibrillation or significant congenital heart defect/disease.
• •Participant has initiated pulmonary rehabilitation within 3 months of screening.
• •Participant is allergic to bovine or porcine products.
• •Participant has evidence of active malignancy, or prior history of active malignancy that has not been in remission for at least 5 years.
• •Participant has a life expectancy of \< 6 months.