HD Melphalan and SCT in Patients With IGDD or LCDD

OBJECTIVES: * To assess the tolerability of high-dose melphalan and autologous stem cell transplantation in patients with immunoglobulin deposition disease or light-chain deposition disease. * To determine the hematologic response rate in patients treated with this regimen. * To determine the predictability of early free light-chain response for heme response in patients treated with this regimen. * To determine organ or clinical response in patients treated with this regimen. * To determine overall survival of these patients. OUTLINE: * Stem cell mobilization: Patients undergo blood stem cell mobilization comprising filgrastim (G-CSF) subcutaneously once daily for 3 days (i.e., through the day before the last stem cell collection). * Stem cell collection: Patients undergo collection of G-CSF-mobilized blood stem cells until the target number of stem cells (at least 2 x 10\^6 cluster of differentiation-34-positive cells) is reached. * Conditioning regimen: Patients receive high-dose melphalan IV on days -3 to -2. * Autologous stem cell transplantation: Patients undergo blood stem cell infusion on day 0. After completion of study therapy, patients are followed at 3, 6, and 12 months and then annually thereafter.