Bowman-Birk Inhibitor Concentrate in Healthy Men

You may be eligible if

• Healthy male participant recruited from the Philadelphia, Pennsylvania metropolitan area
• ECOG performance status 0-2
• WBC ≥ 3,000/uL
• Differential (i.e., neutrophils, lymphocytes, monocytes, bands, eosinophils, and basophils) normal
• Platelet count normal
• Hemoglobin normal
• Hematocrit normal
• RBC normal
• Creatinine normal
• Bilirubin normal
• ALT and AST normal
• Amylase and lipase normal
• Glucose normal
• Cholesterol normal
• Triglycerides normal
• Non-smoker
• * Former smokers are eligible provided they have not smoked within the past 3 months
• Within 15% of ideal body weight based on standard weight tables
• No vegetarians or individuals who normally ingest large amounts of soy products, defined as two or more servings of tofu, soy milk, or other primarily soy-based food per day
• No prior allergy or adverse reaction to soybeans
• No diagnosis of cancer within the past 5 years except nonmelanoma skin cancer
• No prior diagnosis of pancreatitis, pancreatic carcinoma, pancreatic adenoma, diabetes mellitus, obstruction of pancreatic ducts, or amyloidosis
• No history of heart disease
• EKG normal (normal variants allowed)
• No evidence of psychiatric problems
• No history of excessive alcohol consumption (i.e., an average of \> 2 alcoholic beverages per day)
• No alcohol consumption within the past 3 days
• No history of any medical condition that could influence gastrointestinal uptake of the drug
• No history of chronic medical condition
• No evidence of another life-threatening disease
• More than 12 months since prior chemotherapy
• More than 1 month since prior experimental drugs
• More than 2 weeks since prior and no concurrent regular use (i.e., \> 3 times/week) of nonsteroidal anti-inflammatory drugs (NSAIDs)
• More than 2 weeks since prior and no concurrent multivitamin tablets (or other vitamin supplements) of \> 2 per day