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Corneal Collagen Cross-Linking for Ectasia (CXL) | Clinical Trials | Clareo Health

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COMPLETEDPhase 3NCT00674661

Corneal Collagen Cross-Linking for Ectasia (CXL)

Prospective, randomized multicenter study to determine the safety and effectiveness of performing corneal collagen cross-linking (CXL) using riboflavin and UVA light in eyes with ectasia after refract...

Lead sponsor: Glaukos Corporation•10 U.S. locations•View source on ClinicalTrials.gov

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Sponsors

Lead Sponsor

Glaukos Corporation

Subjects are randomized to a control group or a treatment group, with the control group crossed over to the treatment group at the 3 month visit. Corneal collagen cross-linking is performed as a single treatment. Subjects are followed for 12 months after the procedure to evaluate the long term effects of corneal collagen cross-linking.

Age

14 - No limit years

Sex

ALL

Healthy Volunteers

No

Inclusion Criteria

•Diagnosis of ectasia after refractive surgery
•Documented ectasia on Pentacam or topography map
•BSCVA worse than 20/20
•Must complete all study visits

Exclusion Criteria

•History of delayed wound healing
•History of corneal melt or corneal dystrophy

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: April 26, 2021Terms

Trial snapshot

StatusCOMPLETED

PhasePHASE3

Enrollment130

Start dateDec 2007

Last updatedApr 26, 2021

Condition

Locations shown

Shiley Eye Center

La Jolla, California

Gordon -Weiss Vision Institute

San Diego, California

Center for Excellence in Eye Care

Miami, Florida

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: April 26, 2021Data synced to Clareo: May 25, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions