A Phase III Study of Travoprost/Timolol Combination in Patients With Open-Angle Glaucoma or Ocular Hypertension

Exclusion Criteria

• •Females of childbearing potential who are pregnant, planning to become pregnant during the study period, breast-feeding, or not using adequate birth control measures.
• •Any form of glaucoma other than open-angle glaucoma (with or without a pigment dispersion or pseudoexfoliation component) or confirmed ocular hypertension.
• •History or current evidence of chronic or recurrent severe inflammatory eye disease in either eye.
• •History or current evidence of clinically relevant or progressive retinal disease such as retinal degeneration, diabetic retinopathy, or retinal detachment in either eye.
• •Best-corrected visual acuity (BCVA) worse than 0.6 logMAR in either eye.
• •Severe central visual field loss in either eye.
• •Not able to safely discontinue use of all IOP-lowering ocular medication(s) according to the Ocular Hypotensive Medication Washout Schedule.
• •History or current evidence of bronchial asthma, or severe chronic obstructive pulmonary disease (COPD) that would in the opinion of the investigator preclude the safe administration of a topical beta-blocker.
• •History or other evidence of severe illness or any other conditions which would make the subject, in the opinion of the investigator, unsuitable for the study.