Effect of Exercise on Biomarkers of Colon Cancer Risk

Exclusion Criteria

• •Colorectal cancer at any time; any other invasive cancer within the past 10 years (simple basal or squamous cell carcinoma okay)
• •Plans to leave Western Washington during the follow-up period
• •Morbidly obese (BMI \> 41), weight loss of \> 10 pounds in the previous 3 months
• •Familial polyposis, Gardner's syndrome, or other known familial colorectal cancer syndrome
• •Ulcerative colitis or short bowel
• •"Excessive"(\> 3 x week) laxative or enema use that might interfere with rectal crypt studies
• •Current use of certain medications likely to interfere with success of the intervention, or with outcomes measures (for example, anticoagulants because of risk from colorectal biopsy, diet medications within past 6 months)
• •Diabetes mellitus or fasting glucose \> 140
• •Hemochromatosis- if diagnosed by physician
• •Abnormal screening labs (hematocrit \< 32 or \> 48, white blood cells \< 3.0 or \> 15.0, potassium \< 3.5 or \> 5.3, fasting glucose \> 140, creatinine \> 2.0), or abnormalities on screening physical exam judged by study physicians to contraindicate participation in an exercise program
• •Contraindications for entry into a training program 131 including: unstable angina, uncontrolled hypertension (systolic \> 200, diastolic \> 100), orthostatic hypotension (\>20 mm fall in systolic), moderate/severe aortic stenosis, uncontrolled arrhythmia, uncontrolled congestive heart failure, third degree heart block, pericarditis, myocarditis, pulmonary/systemic embolism within the past 6 months, thrombophlebitis, ST displacement \> 3 mm at rest, history of cardiac arrest)
• •Contraindications for exercise testing 131 including: recent (within 6 months) cardiac event (MI, pulmonary edema, myocarditis, pericarditis), unstable angina, uncontrolled arrhythmia, third degree heart block, left bundle branch block, acute congestive failure, recent (within 6 months) pulmonary/systemic embolus, severe electrolyte abnormality
• •Meets criteria to stop screening exercise test 131 as decided by overseeing physician
• •Volunteering in order to lose weight; alcohol or drug abuse, significant mental or emotional problems such as would interfere with compliance (as assessed by study staff impression)