Finding studies
Finding studies
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Lead
Fred Hutchinson Cancer Center
The specific aims of the proposed study are: 1. To measure the effects of a one-year moderate/vigorous intensity aerobic exercise program vs. a delayed-exercise control program in persons that have undergone a colonoscopy within the past 36 months on proliferation rate in the upper part of colon and rectal mucosa crypts. 2. To also measure the effects of a one-year moderate/vigorous intensity aerobic exercise program vs. delayed-exercise control program in persons that have undergone a colonoscopy within the past 36 months on: * expression of apoptosis-related proteins (bax/bcl-2 ratio) in colon and rectal mucosal biopsies * rectal mucosal prostaglandin levels * fasting serum/plasma insulin, glucose, triglycerides, insulin-like growth factor 1(IGF-1), and IGF binding protein-3 (IGFPB-3) * body fat mass and distribution (body mass index, waist and hip circumferences, bioelectrical impedance, DEXA scan) * subcutaneous abdominal and intra-abdominal fat mass (measured by one-slice CT scan at the L4 level) * fitness (VO2max) * quality of life (measured by standardized self-report instruments) * sleep quality
Age
40–75
Sex
ALL
Healthy volunteers
Accepted