Safety and Tolerability of 4975 in the Treatment of Moderate to Severe Knee Pain Due to Osteoarthritis (OA)

Exclusion Criteria

• •Female patients who are pregnant or lactating or who plan to get pregnant.
• •Clinically significant form of joint disease other than OA.
• •Medical condition that could adversely impact the patient's participation, safety or affect the conduct of the study.
• •Prior major trauma in the target knee or major surgeries such as partial or total knee arthroplasty.
• •Arthroscopic surgery on the target knee within 6 months.