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Lead
Creighton University
With
Solae, LLC
Post menopausal estrogen deficiency causes physiologic changes in body composition including decreased lean body weight and bone mass. A decrease in muscle strength along with osteoporosis puts post menopausal women at a high risk of hip fractures causing considerable mortality and morbidity. Estrogen use has been shown to reduce bone density loss and increase muscle strength but given the concerns regarding its use, patients are looking for alternatives such as Soy isoflavones. Most human studies on the effect of Soy on bone mineral density (BMD) in post menopausal women have been short term i.e. 3-6 months and failed to provide conclusive evidence. There is no evidence of its effects on physical performance.
The aim of the present study is to investigate the effects of 25g of soy protein alone or with 90mg of isoflavones on bone mineral Density and physical performance indices in post menopausal women over a duration of 2 years.
Age
55–72
Sex
FEMALE
Healthy volunteers
Accepted
You may be eligible if
at least 55-75 years of age
at least 7 years post menopausal either spontaneous or surgical
You may not be if
must not have used estrogen for atleast 2 months prior to entering study
must be on no bone active drugs such as bisphosphonates, anti convulsants, calcitonin and long term steroids
