Pregnant or nursing

Received a non-FDA approved investigational agent within last 28 days

Received cyclosporin, intravenous immunoglobulin (IVIG) or plasmapheresis within last 6 months

Active lupus nephritis requiring hemodialysis, intravenous cyclophosphamide (Cytoxan™), or high-dose prednisone (\> 100 mg/day) within last 6 months

Active central nervous system (CNS) lupus requiring medical intervention within last 6 months

History of renal transplant

History of clinical evidence of an active significant acute or chronic diseases

Have required management or hospitalization of any infection within last 4 weeks.

History of hypogammaglobulinemia or IgA deficiency

Have current drug or alcohol addiction

History of or test positive at screening for HIV, Hepatitis B or Hepatitis C

Phase 1 Study of Belimumab in Subjects With Systemic Lupus Erythematosus (SLE)