Currently have or have history of certain study-specified heart, liver, kidney, lung, neurological, immune, or other medical conditions

Systemically active steroid use

Another investigational product within 28 days prior to receiving study drug

Major surgery or significant traumatic injury (or unhealed surgical wounds) occurring within 28 days prior to receiving study drug

Chemotherapy, radiation, or biological cancer therapy within 28 days prior to receiving study drug

No known history or evidence of CNS metastases \< 2 years.

Pregnant or lactating

Unwilling or unable to comply with study procedures

Study of Colon GVAX and Cyclophosphamide in Patients With Metastatic Colorectal Cancer