Age

18–65

Sex

ALL

Healthy volunteers

Not accepted

group A: first diagnosis of PCNSL, histologically confirmed
group B: relapse or progression of PCNSL after MTX containing chemotherapy
age 18 - 65 years
not legally incompetent, physically or mentally incapable of giving consent
written signed and dated informed consent of the legal representative and - if possible - of the patient

manifestations of further lymphoma outside the CNS
sero-positive for HIV
severe pulmonary, cardiac, hepatic, renal impairment
neutrophil count \< 2.000/µl, platelet count \< 100.000/µl
pulmonary disease with IVC \< 55%, DLCO \< 40%
cardiac ejection fraction \< 50%, uncontrolled malign arrhythmia
creatinine \> 1,5 mg% or creatinine-clearance \< 50ml/min
bilirubin \> 2mg/dl
ascites or pleural effusion (\> 500ml)
pregnancy o r lactation
women with childbearing potential without sufficient contraception
participation in another clinical trial within the last 30 days prior to the begin or parallel to this study
known or current drug or alcohol abuse
known hypersensitivity against methotrexate, cytarabine, thiotepa, BCNU rituximab, leukovorin, dexamethasone, neupogen and neulasta.

Freiburg ZNS-NHL Study