Serious psychological disease

Pregnancy and inadequate or not secure contraception or breastfeeding women

Other previous malignant disease in the past two years

Serious systemic concomitant diseases, excluding participation in a trial

Other experimental treatment during or within 6 weeks prior to this trial (including chemotherapeutic medicine or immune-therapies)

Every other condition or therapy assessed by the physician as an eventual risk for the patient or restricting the aims of the trial

Distant metastasis

Randomized Controlled Trial of Gemcitabine Combined With 125I Brachytherapy