Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
OHSU Knight Cancer Institute
With
Genentech, Inc.
OSI Pharmaceuticals
Age
18–80
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Patients must fulfill all of the following criteria to be eligible for study entry:
Age 18-80
Able to provide informed consent
Biopsy proven unresectable metastatic adenocarcinoma of the colon or rectum
Documented progression on prior first-line oxaliplatin-based or irinotecan-based regimen for metastatic colorectal cancer
Radiographically measurable disease with at least one bidimensionally measurable lesion of \> 1 cm
Prior first-line regimen must have been completed at least 4 weeks prior to study treatment
Use of biologic agents with first-line chemotherapy permitted
Previous adjuvant regimens must have been greater than 6 months before inclusion
Adequate organ function including bone marrow, liver and renal function as defined by the following values: absolute neutrophil count \> 1500/microliter; Hgb \> 9 g/dL; platelets \> 90,000/microliter; International Normalized Ratio \< 1.8 (unless in therapeutic range if taking warfarin or other warfarin-derivative anticoagulants and are being monitored regularly for changes in prothrombin time or International Normalized Ratio); bilirubin \< 2 times the Upper Limit of Normal; alkaline phosphatase \< 3 times the Upper Limit of Normal; aspartate aminotransferase/alanine aminotransferase \< 5 times the Upper Limit of Normal; serum creatinine \< 1.5 times the Upper Limit of Normal
Eastern Cooperative Oncology Group status \< 2
You may not be if
Patients meeting any of the following criteria are ineligible for study entry:
Prior second-line chemotherapy regimens for colorectal cancer
Prior treatment with erlotinib or gefitinib
Central Nervous System metastasis
Second malignancies less than 5 years prior to enrollment. Completely resected basal or squamous cell carcinoma of the skin is allowed.
Untreated/unresolved bowel obstruction
Inability to take oral mediations
HIV positive
Pregnancy
Other uncontrolled medical illnesses
Current diarrhea \> grade 2
Symptomatic angina or uncontrolled congestive heart failure
