Study of Subcutaneous Methylnaltrexone (MNTX) in the Treatment of Opioid-Induced Constipation During Rehabilitation After Orthopedic Procedures

Inclusion Criteria

• •1. Male and female participants greater than or equal to (\>=) 18 years of age.
• •2. Participants must have undergone an orthopedic procedure (that is, total knee or hip replacement, spinal fusion, or reduction of fracture(s) with or without surgical fixation post trauma).
• •3. Participants must be receiving opioid analgesics (a mu agonist only-not to include agents with mixed mechanisms of action such as tramadol or buprenorphine) after the procedures and be expected to require daily opioid analgesics for at least 7 days post randomization.
• •4. Participants must be acutely constipated following their orthopedic procedure.
• •5. Participants must receive all doses of study drug in either hospitals or rehabilitation facilities.
• •6. Participants must sign an informed consent form.
• •7. Females of childbearing potential must have a negative pregnancy test and use appropriate birth control throughout the study.
• •8. Body weight within range of 40 kilograms (kg) - 150 kg (88 - 330 pounds \[lbs\]).