Loading clinical trials...

COMPLETEDPHASE2/PHASE3

Modification of Cognitive Processing Therapy (CPT-C) for PTSD and Alcohol Dependence

Modification of Cognitive Processing Therapy (CPT-C) for Posttraumatic Stress Disorder (PTSD) and Alcohol Dependence (AD)

NCT00639288•Yale University

View on ClinicalTrials.gov

Summary

Objective: To develop a detailed treatment manual that modifies the existing CPT-C treatment protocol to allow for concurrent treatment of PTSD and AD, and to obtain some pilot data regarding its efficacy. Hypothesis: We predict that CPT-C will significantly reduce the number of drinking days (measured by the Timeline Follow Back Method \[TLFB\]) and reduce the symptoms of PTSD (measured by the \[CAPS and PCL\] scores). Design: This is a non-randomized, prospective study in which all participants will receive the modified CPT-C for 12 weeks by trained CPT-C clinicians, with each session lasting approximately 1-1.5 hours). Modifications to CPT-C include psychoeducation about alcohol use as an avoidance of PTSD symptoms integrated throughout treatment, integration of coping skills training for AD, weekly breathalyzer tests to measure blood alcohol level, and use and collection of daily dairies of alcohol use.

Eligibility

Age

21 - 65 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•1. Males and females between the ages of 21-65 years old.
•2. Current alcohol dependence as determined by the Structured Clinical Interview for DSM-IV Axis I Disorder (SCID; First et al. 1996). Abstinence no more than past 29 days. Primary substance dependence diagnosis of alcohol dependence.
•3. Current PTSD as determined by the Clinician Administered PTSD Scale for DSM-IV(CAPS; Blake et al. 1995).
•4. Participants on psychiatric medication must be on a stable regimen for at least 2 weeks before treatment begins.
•5. Ability to participate psychologically and physically, able to give informed consent and complete assessments, and participate in study procedures.

Exclusion Criteria

•1. Current psychotic disorders
•2. Current suicidal or homicidal ideations
•3. Current substance dependence other than alcohol or nicotine dependence
•4. Legal charges pending with potential of incarceration
•5. Unstable serious medical conditions or one requiring acute medical treatments or anticipation of hospitalization for extended care

Locations (1)

VA Connecticut Healthcare System - West Haven Campus

West Haven, Connecticut, United States

Key Dates

Start Date

March 1, 2008

Primary Completion Date

October 1, 2014

Completion Date

April 1, 2015

Last Updated

March 21, 2016

Enrollment

ACTUAL participants

Conditions

Alcohol DependencePTSD

Interventions

modified CPT-C

OTHER

Testing an Integrated PTSD and Weight Management Intervention: A Hybrid Type 1 Trial

NCT07010757

PTSDObesity

View study

RECRUITINGNA

Digital Biofeedback for Combat Veterans Diagnosed With PTSD

NCT07462312

PTSD - Post Traumatic Stress Disorder

View study

RECRUITINGNA

EMDR Integrative Group Protocol and Individual Treatment for Patients With Cancer: A Pilot Study

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: March 21, 2016Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions

Modification of Cognitive Processing Therapy (CPT-C) for PTSD and Alcohol Dependence

Inclusion Criteria

Exclusion Criteria

Testing an Integrated PTSD and Weight Management Intervention: A Hybrid Type 1 Trial

Digital Biofeedback for Combat Veterans Diagnosed With PTSD

EMDR Integrative Group Protocol and Individual Treatment for Patients With Cancer: A Pilot Study

Augmenting Massed Cognitive Processing Therapy (CPT) to Prevent Suicide Risk Among Patients With PTSD

Effects of Tirzepatide on Alcohol Intake in Patients Diagnosed With Schizophrenia and Alcohol Use Disorder

Parenting STAIR: Adapting a Trauma-Focused Parenting Intervention for Military-Connected Mothers and Their Children