Levetiracetam or Pregabalin in Treating Seizures in Patients Undergoing Chemotherapy and/or Radiation Therapy For Primary Brain Tumors

Inclusion Criteria

• •DISEASE CHARACTERISTICS:
• •Diagnosis of primary brain tumor
• •* WHO grade II-IV disease
• •Undergoing chemotherapy and/or radiotherapy
• •No brain tumor without the potential need for chemotherapy (e.g., meningioma without anaplastic features)
• •Has had at least one seizure provoked by the brain tumor, justifying introduction of antiepileptic drug (AED) treatment
• •* No status epilepticus
• •PATIENT CHARACTERISTICS:
• •Modified Rankin score \< 4 at study enrollment
• •Life expectancy ≥ 4 weeks
• •Not pregnant
• •Negative pregnancy test
• •Fertile patients must use effective contraception
• •No known intolerance to the study drugs
• •No pre-existing psychosis and/or current suicidality
• •PRIOR CONCURRENT THERAPY:
• •See Disease Characteristics
• •No concurrent IV AEDs other than benzodiazepines
• •Other concurrent AEDs, except phenobarbital, allowed provided they are discontinued within 2 weeks after study enrollment