Utility of Amantadine Hydrochloride in the Treatment of Post-traumatic Irritability

Inclusion Criteria

• •Closed head injury (defined as brain injury or impaired brain function resulting from externally inflicted trauma without penetrating injury) at least 6 months prior to enrollment.
• •Age at time of enrollment: 16 - 65 inclusive (i.e., on or after 16th birthday, up to day before 66th birthday).
• •Voluntary informed consent of patient and informant.
• •Subject and informant willing to comply with the protocol, \& are available for all scheduled clinic visits.
• •Neuropsychiatric Inventory (NPI) Irritability Domain score \> 2.
• •Medically and neurologically stable during the month prior to enrollment.
• •If taking antidepressant, anxiolytic, hypnotic, or stimulant medications, no change anticipated in these medications during the month prior to enrollment.
• •No change in therapies or medications planned during the 28-day participation.
• •No surgeries planned during the 28-day participation.
• •Vision, hearing, speech, motor function, and comprehension must be sufficient for compliance with all testing procedures. Ability to interact and verbalize sufficient to participate in assessments.
• •Informant (family member or close friend) who lives with the participant with daily interaction in order to observe occurrences of irritability.