Patients with significant hepatic impairment

Neurological disorders unrelated to diabetic neuropathy that may confuse the assessment of neuropathic pain

Any pain or other condition that may confound assessment or self-evaluation of the pain due to diabetic neuropathy

Amputations other than toes

A current or recent diagnosis (past 6 months) or episode of major depressive disorder and/or uncontrolled depression

History of transient ischemic attack or stroke

Myocardial infarction or unstable angina within the past three months

A Trial Of [S,S]-Reboxetine In Patients With Chronic Painful Diabetic Peripheral Neuropathy.