Lead Sponsor

Pfizer

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

•Male or female of any race at least 18 years of age
•Diagnosis of painful, distal, symmetrical, sensory-motor polyneuropathy, which is due to diabetes, for at least 1 year
•Patients at Visit 1 must have a score ≥40 mm on the Pain Visual Analogue Scale

•Patients with significant hepatic impairment
•Neurological disorders unrelated to diabetic neuropathy that may confuse the assessment of neuropathic pain
•Any pain or other condition that may confound assessment or self-evaluation of the pain due to diabetic neuropathy
•Amputations other than toes
•A current or recent diagnosis (past 6 months) or episode of major depressive disorder and/or uncontrolled depression
•History of transient ischemic attack or stroke
•Myocardial infarction or unstable angina within the past three months