History or known presence of central nervous system (CNS) metastases

Prior chemotherapy or other systemic therapy for advanced or metastatic CRC

Any investigational agent or therapy for advanced or metastatic CRC

Clinically significant cardiac disease

Clinically significant peripheral neuropathy

Active inflammatory bowel disease

Recent gastrointestinal ulcer or hemorrhage

Recent arterial thrombotic event or pulmonary embolus

Recent history of clinically significant bleeding, bleeding diathesis, or coagulopathy

Recent major surgical procedure or not yet recovered from major surgery

Phase 1b/2 Study of AMG 655 With mFOLFOX6 and Bevacizumab for First-Line Metastatic Colorectal Cancer