Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Merz Pharmaceuticals GmbH
Age
50–90
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Male or female outpatient at least 50 years of age and at least 8 years of education.
The patient should have German as a mother-tongue or at least speak the language fluently in order to achieve similar scores in verbal tasks.
Current diagnosis of probable Alzheimer's disease consistent with NINCDS- ADRDA criteria or with DSM IV TR criteria for Dementia of the Alzheimer's type.
Mini Mental State Examination (MMSE) total score is less than 20
Patients treated with any acetylcholinesterase inhibitor (AChEI) may be included, when treatment has started at least 6 months prior screening and was stable during the last 3 months.
You may not be if
Any type of evident aphasia, which may interfere with patient's communication difficulties caused by Alzheimer's disease
History of severe drug allergy, or hypersensitivity, or patients with known hypersensitivity to amantadine, lactose.
Evidence (including CT/MRI results) of any clinically significant central nervous system disease other than Alzheimer's disease.
Modified Hachinski Ischemia score greater than 4 at screening.
Current evidence of clinically significant systemic disease
Known or suspected history of alcoholism or drug abuse within the past 10 years.
Previous treatment with memantine or participation in an investigational study with memantine.
