Contraindication to lamotrigine (Physician interview, medical assessment)
Documented history of intolerance to lamotrigine
Patients who have previously failed to respond to at least 12 weeks of treatment with lamotrigine
Active substance dependence (SCID-I/P) or substance-related safety issues or PI concerns
Mood Disorder Due to a General Medical Condition or Treatment (Physician interview)
Rapid cycling (Physician interview): As defined in DSM-IV: At least 4 episodes of mood disturbance in the previous 12 months that meet criteria for a Major Depressive, Manic, Mixed or Hypomanic Episode. Episodes are distinguished either by partial or full remission for at least 2 months or by a switch to an episode of opposite polarity
Dementia (by DSM-IV or brain degenerative diseases; Physician interview);
Inability to communicate in English (i.e., interview cannot be conducted without an interpreter; subject largely unable to understand questions and cannot respond in English)
Clinically significant sensory impairment (i.e., cannot see well enough to read consent or visually-presented material; cannot hear well enough to cooperate with interview; Physician interview)
Recent history of cardiovascular, peripheral vascular events or stroke
High risk for suicide (e.g., active SI or current intent or plan)
