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CRESTOR Athero Imaging Head to Head IVUS Study | Clinical Trials | Clareo Health

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COMPLETEDPhase 3NCT00620542

CRESTOR Athero Imaging Head to Head IVUS Study

A 104-week, randomized, double-blind, parallel group, multi-center Phase IIIb study comparing the effects of treatment with rosuvastatin 40 mg or atorvastatin 80 mg on atherosclerotic disease burden a...

Lead sponsor: AstraZeneca•97 U.S. locations•View source on ClinicalTrials.gov

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Sponsors

Lead Sponsor

AstraZeneca

Collaborators

The Cleveland Clinic

Age

18 - 75 years

Sex

ALL

Healthy Volunteers

No

Inclusion Criteria

•Clinical indication for coronary angiography
•Angiographic evidence of Coronary Artery Disease (CAD), as defined by at least 1 lesion in a native coronary artery that has \>20% reduction in lumen diameter by visual estimation
•Left main coronary artery must have \<=50% reduction in lumen diameter by visual estimation
•LDL-C \>100 mg/dL (2.6 mmol/L) for patients with no statin therapy in the past 4 weeks; LDL-C \>80mg/dL (2.08mmol/L) for patients on therapy in the past 4 weeks

Exclusion Criteria

•Use of certain lipid-lowering medication for more than 3 months within the previous 12 months. Longer periods of treatment are not permitted because of the potential effects of such therapy on coronary atherosclerosis.
•Patients who have symptoms consistent with moderate or greater severity of Congestive Heart Failure (CHF).
•Clinically significant heart disease which, in the opinion of the Principal Investigator (or designee), is likely to require coronary bypass surgery, cardiac transplantation, surgical repair and/or replacement during the course of the study

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: July 16, 2012Terms

Trial snapshot

StatusCOMPLETED

PhasePHASE3

Enrollment2,333

Start dateJan 2008

Last updatedJul 16, 2012

Condition

Coronary Atherosclerosis

Locations shown

Research Site

Huntsville, Alabama

Research Site

Los Angeles, California

Research Site

Mountain View, California

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: July 16, 2012Data synced to Clareo: May 3, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions