Effects of Smoking on Opioid Receptor Binding: A PET Study

Exclusion Criteria

• •1. interest in reducing or quitting tobacco use
• •2. treatment for nicotine dependence in the past 3 months
• •3. current drug or alcohol abuse or dependence
• •4. consumption of more than 15 alcoholic drinks per week during the past month
• •5. any opiate use in the past 6 months
• •6. marijuana use greater than one time per week on an average during the past month
• •7. other drug use greater than 2 time per month on average during the past 3 months.
• •8. current use of any medication that would interfere with the protocol
• •9. under the influence of a drug or alcohol at experimental sessions
• •10. HIV positive
• •11. history of psychotropic medications
• •12. history of head injury with unconscious longer than 5 minutes
• •13. implantable device or foreign body that would make an MRI examination unobtainable
• •14. MRI abnormality judged clinically significant by the PI
• •15. use of any investigational medication or device within the previous 30 days
• •16. donation at least 450 ml of blood or equivalent levels of plasma within the previous 30 days
• •17. exposure to ionizing radiation that, in combination with the study tracer, would result in a cumulative exposure exceeding 5 rem in one calendar year
• •18. any subject judged by the PI to be inappropriate for the study.
• •19. chronic pulmonary disease, including COPD, bronchitis, asthma, and emphysema
• •20. pregnant, nursing, or become pregnant during the study
• •1. use of any tobacco products in the past year
• •2. current drug or alcohol abuse or dependence
• •3. consumption of more than 15 alcoholic drinks per week during the past month
• •4. any opiate use in the past 6 months
• •5. marijuana use greater than one time per week on average during past month
• •6. other drug use greater than two times per month on average during past three months.
• •7. current use of any medication that would interfere with the protocol
• •8. under the influence of a drug or alcohol at experimental sessions
• •9. HIV positive
• •10. history of psychotropic medications
• •11. history of head injury with unconscious longer than 5 minutes
• •12. implantable device or foreign body that would make an MRI examination unobtainable
• •13. MRI abnormality judged clinically significant by the PI
• •14. use of any investigational medication or device within the previous 30 days
• •15. donation of at least 450 ml of blood or equivalent levels of plasma within the previous 30 days
• •16. exposure to ionizing radiation that, in combination with the study tracer, would result in a cumulative exposure exceeding 5 rem in one calendar year
• •17. any subject judged by the PI to be inappropriate for the study.
• •18. chronic pulmonary disease, including COPD, bronchitis, asthma, and emphysema
• •19. pregnant, nursing, or become pregnant during the study