Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Yale University
Age
21–45
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
1. Ages of 21-45 years from all ethnic backgrounds.
2. Male or female.
3. Written informed consent.
4. Female subjects will be studied during the follicular phase of their menstrual cycle.\*
1. Ages of 21-45 years from all ethnic backgrounds.
2. Male or female.
3. Written informed consent.
4. DSM-IV diagnosis of schizophrenia or schizoaffective disorder.
5. For treated patients: The patient has been on a stable dose of medications (antipsychotics, antidepressants) for the past month and does not require a change of medications or dose adjustment at study entry.
6. For untreated patients: Has refused to be treated with medications, maintains regular clinic appointments with the clinicians, and does not pose an imminent danger to himself or others.
7. Female subjects will be studied during the follicular phase of their menstrual cycle\*.
You may not be if
1. DSM-IV diagnosis of psychotic, anxiety, mood disorder.
2. A history of significant medical/neurological disease. Unstable medical condition based on EKG, vital signs, physical examination and laboratory work-up (CBC with differential, SMA-7, LFTs, TFTs, UA, Utox, Urine pregnancy test, folic acid, B12 levels).
3. History of allergies to drugs such as sulfa, multiple adverse drug reactions or known allergy to furosemide.
4. Any medication that in the opinion of the PI could interfere with either the safety of the study and/or the outcome measures, such as over the counter cough suppressants or antihistamines.
5. History of major psychiatric disorder in first-degree relatives.
6. Current substance abuse/dependency determined by plasma and urine toxicology.
7. Current treatment with medications with psychotropic effects.
8. Current pregnancy, unsatisfactory birth control method report for females.
9. Education \< 12th grade.
10. Non-English speaking.
1. A history of significant medical/neurological disease. Unstable medical condition based on EKG, vital signs, physical examination and laboratory work-up (CBC with differential, SMA-7, LFTs, TFTs, UA, Utox, Urine pregnancy test, folic acid, B12 levels).
4. History of allergies to drugs such as sulfa, multiple adverse drug reactions or known allergy to furosemide.
5. Any medication that in the opinion of the PI could interfere with either the safety of the study and/or the outcome measures, such as over the counter cough suppressants or antihistamines.
6. Current use of lithium (lithium directly interferes with electrolyte balance).
7. Currently on clozapine as clozapine may interfere with brain water regulation (Leadbetter and Shutty, 1994).
8. Current substance abuse/dependency determined by plasma and urine toxicology.
9. Current treatment with benzodiazepines or mood stabilizers (these medications can alter glutamate transmission).
10. Current pregnancy, unsatisfactory birth control method report for females.
11. IQ \< 70 as determined by Wechsler Abbreviated Scale of Intelligence.
