Histologically proven melanoma

For subjects with brain metastases that require radiation, therapy must have been completed at least 4 weeks prior to Day 1 of Study Drug

Have unresectable melanoma with measurable metastases

Be a minimum of 4 weeks since prior surgical resection or major surgical procedure and a minimum of 2 weeks since chemotherapy/ biochemotherapy

Performance score of Karnofsky ≥ 60%, or Eastern Cooperative Oncology Group (ECOG) ≤ 2, or WHO ≤ 2

If steroids are needed, be on a stable or decreasing dose of steroids for at least 1 week

Phase 1 Study of MPC-6827 and Temozolomide in Metastatic Melanoma