Investigation Of a New Oral Anti-Histamine in Healthy Male Subjects

Exclusion Criteria

• •As a result of the medical interview, physical examination or screening investigations, the Investigator or appropriately qualified designee considers the subject unfit for the study.
• •The subject has a history of drug or any other allergy, which, in the opinion of the Investigator or appropriately qualified designee, contraindicates their participation, including known or suspected personal history or family history of adverse reactions or hypersensitivity to anti histamines.
• •The subject has participated in a study with a new molecular entity during the previous 3 months or any other study during the previous 2 months.
• •The subject regularly, or on average, drinks more than 21 units of alcohol a week or more than an average intake of 3 units per day (One unit = 125ml wine or 25ml spirits or 250ml normal strength lager).
• •The subject is currently taking regular (or a course of) medication, prescribed (including all anti-allergy medication) or not (including over the counter medication or herbal remedies such as St Johns Wort). Paracetamol is an exception and will be permitted at daily doses of up to 4g following all doses of investigational product.
• •The subject has tested positive for hepatitis C antibody or hepatitis B surface antigen.
• •The subject has tested positive for HIV.
• •The subject has a positive drugs of abuse and alcohol test.
• •Donation of blood (450 mL or more) within 2 months of screening.
• •Donation during the study would result in \>500mL of blood being donated over a 56 day period
• •Significant cardiac conduction abnormalities on two or more ECG tracings separated by at least 5 minutes at screening, including:
• •* QTc interval \> 450 msec
• •* PR interval \> 240 msec
• •* Evidence of second- or third- degree atrioventricular (AV) block
• •* Ventricular rate \< 45 beats per minute (bpm) or \> 100 bpm
• •* Pathological Q-waves (defined as Q-wave \> 40 msec or depth greater than 0.4-0.5 mV)
• •* Evidence of ventricular pre-excitation
• •* Evidence of left axis deviation, non-specific intraventricular conduction delay (QRS duration \> 120 msec), or complete left bundle branch block
• •Subjects with Perennial Allergic Rhinitis (PAR) and Seasonal Allergic Rhinitis (SAR), unless subjects with SAR are asymptomatic and it is outside of the pollen season
• •Subjects with dermatographism and other skin conditions that might interfere with the wheal and flare test.
• •Subjects who are unable to comply with study procedures.