SD Cystic Fibrosis Study

Exclusion Criteria

• •Any clinically abnormality found at screening that is not part of the disease of cystic fibrosis.
• •any problem with pancrease
• •fatty feces
• •liver problems
• •sudden weight loss or poor nutritional status.
• •high blood pressure
• •infected with the hepatitis B, hepatitis C, or HIV virus
• •History of regular alcohol use
• •a current non-smoker
• •uses corticosteroids; regular use of high dose NSAIDs, within 2 months of study start.
• •have had positive Burkholderia cepacia, or MRSA within the last 12 months
• •on treatment for any mycobacterial infection
• •cannot be withdrawn from oral azithromycin during study
• •any marked bleeding haemoptysis in the last 12 months.
• •has taken more than 4 new chemical entities within the last year.
• •donate more than 500 mL within the last 56 day.
• •taken part in a drug trial in 30 days or taken part in a trial with a new chemical within the last 2 months.
• •on drugs that are CYP3A4, CYP2B6, CYP2C8 or OATP1B1 substrates with a narrow therapeutic index are excluded.
• •using non-prescription drugs, including, herbal and dietary supplements (including St John's Wort) within 7 days or unless permitted by the Investigator and sponsor
• •Consumption of grapefruit juice in last 7 seven day before study start.
• •Pregnant or breast feeding.