BRAVO Study: Laquinimod Double-blind Placebo-controlled Study in Participants With Relapsing-Remitting Multiple Sclerosis (RRMS) With a Rater Blinded Reference Arm of Interferon β-1a (Avonex®)

Exclusion Criteria

• •1. An onset of relapse or any treatment with corticosteroids (intravenous \[iv\], intramuscular \[im\] and/or per os \[po\]) or ACTH between month -1 (screening) and 0 (baseline).
• •2. Use of experimental or investigational drugs, and/or participation in drug clinical studies within the 6 months prior to screening.
• •3. Use of immunosuppressive (including Mitoxantrone (Novantrone®) or cytotoxic agents within 6 months prior to the screening visit.
• •4. Previous use of either of the following: natalizumab (Tysabri®), cladribine or laquinimod.
• •5. Previous treatment with glatiramer acetate (Copaxone®) or IVIG within 3 months prior to screening visit.
• •6. Previous treatment with Interferon beta-1a (Avonex® or Rebif®) or Interferon beta-1b (Betaseron®).
• •7. Systemic corticosteroid treatment of ≥30 consecutive days duration within 2 months prior to screening visit.
• •8. Previous total body irradiation or total lymphoid irradiation.
• •9. Previous stem-cell treatment, autologous bone marrow transplantation or allogenic bone marrow transplantation.
• •10. A known history of tuberculosis.
• •11. Acute infection 2 weeks prior to baseline visit.
• •12. Major trauma or surgery 2 weeks prior to baseline visit.
• •13. A history of vascular thrombosis (excluding catheter-site superficial venous thrombophlebitis).
• •14. A carrier state of factor V Leiden mutation (either homo- or heterozygous) by history or as disclosed at screening.
• •15. Positive screening test for Hepatitis B surface antigen, Hepatitis C antibody, or HIV antibody as disclosed at screening visit.
• •16. Use of potent inhibitors of CYP3A4 within 2 weeks prior to baseline visit (see detailed list of drugs in protocol) (1 month for fluoxetine).
• •17. Use of amiodarone within 2 years prior to screening visit.
• •18. Pregnancy or breastfeeding.
• •19. Subjects with a clinically significant or unstable medical or surgical condition that would preclude safe and complete study participation, as determined by medical history, physical examinations, ECG, laboratory tests or chest X-ray. Such conditions may include:
• •* A cardiovascular or pulmonary disorder that cannot be well-controlled by standard treatment permitted by the study protocol.
• •* A gastrointestinal disorder that may affect the absorption of study medication.
• •* Renal, metabolic, endocrinological or hematological diseases.
• •* Any form of chronic liver disease, including known non-alcoholic steatohepatitis.
• •* A ≥2xULN serum elevation of either of the following at screening: ALT, AST or direct bilirubin.
• •* A QTc interval (obtained from either two ECG recordings at screening or from the mean value calculated from three measurements at baseline visit) which is ≥450msec.
• •* A family history of Long-QT syndrome.
• •* A history of drug and/or alcohol abuse.
• •* Major psychiatric disorder.
• •* A history of a convulsive disorder.
• •* Known hypersensitivity to either of the following: mannitol, meglumine or sodium stearyl fumarate.
• •* Known hypersensitivity that would preclude administration of laquinimod.
• •20. The subject's inability to give informed consent, or to complete the study, or if the subject is considered by the investigator to be, for any reason, an unsuitable candidate for this study.
• •21. A known history of sensitivity to Gadolinium.
• •22. Inability to successfully undergo MRI scanning.
• •23. A known history of hypersensitivity to natural or recombinant interferon beta, human albumin, or any other component of the formulation of Avonex®.
• •24. Subjects who suffer from any form of progressive MS
• •25. Any condition which the investigator feels may interfere with participation in the study
• •26. Subjects with a clinically significant or unstable medical or surgical condition that would preclude safe and complete study participation
• •27. Subjects who received any investigational medication, immunosuppressives or cytotoxic agents within 6 months prior to screening
• •28. Previous treatment with immunomodulators within two months prior to screening
• •29. Pregnancy or breastfeeding