Erlotinib and Surgery in Treating Patients With Head and Neck Cancer That Can Be Removed by Surgery

OBJECTIVES: Primary * Identify tissue biomarkers (primarily the level of phosphorylation of individual C-terminal EGFR tyrosine sites, measured by nano-LC-MS/MS and markers of main downstream pathways activation such as P-AKT and P-ERK, measured by nano-LC-MS/MS and by more clinically standardized IHC) that best associate with response to neoadjuvant erlotinib hydrochloride treatment in patients with resectable squamous cell carcinoma of the head and neck (HNSCC). * Determine the best correlations between levels and changes of different individual biomarkers (e.g., levels of C-terminal EGFR phosphorylation and recruited adaptors and markers of downstream pathways activation) in order to evaluate the mechanisms of EGFR pathway activation in HNSCC and mechanisms of EGFR pathway inhibition by erlotinib hydrochloride in HNSCC tissue. * Evaluate post-erlotinib hydrochloride up-regulation of different receptors and molecules such as HER2 and 3, PDGFR, IGFR, mTOR, src, and aurora kinases, for which there are already specific inhibitors available for clinical studies. Secondary * Evaluate the efficacy by overall response, safety, and tolerability of erlotinib hydrochloride before surgery in these patients. * Evaluate the role of FDG-PET scan as a predictor of response to erlotinib hydrochloride. * Evaluate the role of PET/CT in measuring the response to short-term treatment with erlotinib hydrochloride. * Evaluate incidence of risk factors for relapse in the surgical pathology specimens. OUTLINE: Patients are grouped according to smoking status (non-actively smoking \[not smoking, smoking an average of \< 10 cigarettes daily, or smoking for \< 1 year prior to enrollment\] vs actively smoking \[smoking an average of ≥ 10 cigarettes daily and smoking for ≥ 1 year\]). * Non-actively smoking patients: Patients receive oral erlotinib hydrochloride 150 mg once daily for at least 14 days. At day 15 patients undergo surgical resection of the tumor. * Actively smoking patients: Patients receive oral erlotinib hydrochloride 300 mg once daily for at least 14 days. At day 15 patients undergo surgical resection of the tumor. Patients undergo biopsies at baseline and after completion of study treatment. Tissue samples are analyzed by nano-liquid chromatography and mass spectrometry (nano-LC-MS/MS) for markers of activation and inhibition of different EGFR downstream pathways: PKC, c-Cbl, P-Erk, P- Akt, P-RAF, src, STAT3 and 5, cyclin D1, and D3, p21 and p27, c-fos, E-cadherin, vimentin, and correlative up-regulated receptors: Her 2, Her 3, Cox-2, IGF, VEGF, PDGFR, or other kinases such as src and aurora kinases A and B. The results are confirmed by western blot, protein array, and immunohistochemistry. After completion of study treatment, patients are followed at 1 month.