Lead Sponsor

Jazz Pharmaceuticals

Age

50 - 75 years

Sex

ALL

Healthy Volunteers

No

•Diagnosis of moderate or severe classic essential tremor (bilateral, largely symmetric postural or kinetic tremor involving hands and forearms.
•Willingness to abstain from ethanol and caffeine intake for at least 48 hours prior to Days 1 and 4 and on inpatient days

•Subjects with a clinically significant unstable medical abnormality, chronic disease or history or presence of significant hepatic, renal, endocrine, cardiovascular, gastrointestinal, pulmonary, psychiatric, or metabolic disease or any other abnormality
•Subjects who are on sodium-restricted diets
•Subjects with a known history of sleep apnea