Getting Biased Treatment Study: How Psychotherapy and Antidepressants Change Brain Activity in Chronic Depression

Impact of Therapeutical Strategies on Emotional Processing in Depression: Neurofunctional and Clinical Issues in the Context of Affective Bias

NCT00596986•Charite University, Berlin, Germany

View on ClinicalTrials.gov

Summary

The purpose of this study is to determine how psychotherapy and pharmacotherapy respectively change brain activity in patients suffering from chronic depression.

Eligibility

Age

18 - 55 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Chronic Depression (Double Depression, Chronic MDE, MDE with incomplete remission)
•HAMD-24\>20

Exclusion Criteria

•Concurrent Psychotherapy or Psychopharmacotherapy
•Previous Non-Response to Duloxetine
•Non-Response to three Antidepressants of two different groups given at adequate doses or Non-Response to two empirically tested forms of Psychotherapy in the current Depressive Episode
•Serious Psychiatric comorbidity
•Serious Neurologic comorbidity
•Contraindications to Duloxetine
•Contraindications to fMRI

Locations (1)

Charité Universitätsmedizin

Berlin, State of Berlin, Germany

Key Dates

Start Date

October 1, 2008

Primary Completion Date

September 1, 2009

Last Updated

August 3, 2009

Enrollment

ESTIMATED participants

Conditions

Chronic Depression

Interventions

Duloxetine

DRUG

Cognitive Behavioural Analysis System of Psychotherapy

BEHAVIORAL

A Multiple Case Study of Schema Therapy for Difficult-to-treat Depression- DEPRE-ST*Case

NCT06655623

DepressionMajor Depressive Disorder+2 more

View study

COMPLETEDNA

Intensive Psychotherapy for Chronic Depression

NCT05221567

Chronic DepressionPersistent Depressive Disorder+1 more

View study

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: August 3, 2009Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions