Lead Sponsor

Massachusetts General Hospital

Age

6 - 12 years

Sex

ALL

Healthy Volunteers

No

•Male and female outpatients 6 to 12 years of age.
•Diagnosis of Attention Deficit Hyperactivity Disorder (ADHD), by DSM-IV, as manifested in clinical evaluation and confirmed by structured interview.
•Participation in structured morning routine (e.g. school, camp, or other organized activities).

•Mental retardation (IQ \<75).
•Subjects with a medical condition, or treatment that will either jeopardize subject safety or affect the scientific merit of the study.
•Subjects with moderate to severe dermatological atopy.
•Subjects with known structural cardiac abnormalities.
•Organic brain disorders.
•Seizure Disorder.
•Subjects with Tourette's syndrome, or a history of psychosis or bipolar disorder.
•Subjects with current comorbid psychopathology that in the investigator's opinion will warrant immediate treatment or will interfere with the safe execution of the protocol (i.e. Anxiety or Major Depressive Disorder rated as moderate on CGI).
•Subjects with a history of intolerable adverse effects or non-response to methylphenidate.
•Pregnant or nursing females.