Trial In Pediatric Patients With Familial Adenomatous Polyposis (FAP)

Inclusion Criteria

• •Age 10-17 years
• •Confirmed deleterious FAP genotype based on central genetic testing or personal history ot \>2 colorectal adenomas and a parent with the diagnosis of FAP and either A, B or C below A: Non-attenuated FAP genotype B: Attenuated FAP genotype and a personal history of colorectal adenomas and a first degree relative with FAP C: No genotype identified with a personal history of \> 2 adenomas and have a parent with FAP
• •Less than 30 polyps, which need to be removed to render the colon polyp-free before study drug can be given