Memantine Treatment Study of Pathological Gambling

Exclusion Criteria

• •Infrequent gambling (i.e. less than one time per week) that does not meet DSM-IV criteria for PG;
• •Unstable medical illness or clinically significant abnormalities on laboratory tests, EKG, or physical examination at screen;
• •History of seizures;
• •Myocardial infarction within 6 months;
• •Current pregnancy or lactation, or inadequate contraception in women of childbearing potential;
• •A need for medication other than memantine with possible psychotropic effects or unfavorable interactions;
• •Clinically significant suicidality;
• •Current Axis I disorder determined by the SCID and SCID-compatible modules for impulse control disorders (Grant et al., 2005), except for nicotine dependence;
• •Lifetime history of bipolar disorder type I or II, dementia, schizophrenia, or any psychotic disorder determined by SCID;
• •Current or recent (past 3 months) DSM-IV substance abuse or dependence;
• •Positive urine drug screen at screening;
• •Initiation of psychotherapy or behavior therapy within 3 months prior to study baseline;
• •Previous treatment with memantine;
• •Treatment with investigational medication or depot neuroleptics within 3 months, with fluoxetine within 6 weeks, or with other psychotropics within 2 weeks prior to study baseline.