Protein and Energy Metabolism in Pediatric Crohn's Disease

Exclusion Criteria

• •Local manifestations of Crohn's disease, including fistula(s), strictures, abscesses, or other complications for which surgery may be indicated.
• •Surgery for bowel diversion with placement of stoma within 3 months prior to screening.
• •Positive stool examination of enteric pathogens including Salmonella and Shigella species, Clostridium difficile, and Giardia lamblia.
• •Female subjects who are pregnant, nursing, or planning pregnancy.
• •Concomitant diagnosis or history of congestive heart failure.
• •Treatment with parenteral nutrition within 4 weeks of enrollment.
• •Serious infection in the 3 months prior to enrollment.
• •History of prior or current active or latent tuberculosis.
• •Immune deficiency syndrome, including documented human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS).
• •History of systemic lupus erythematosus.
• •A transplanted organ.
• •Known malignancy or history of malignancy within 5 years of enrollment.
• •History of demyelinating disease.
• •History of substance abuse.
• •Poor tolerability of venipuncture or lack of venous access during the study period.
• •A live virus vaccination within 3 months of enrollment.
• •Prior history of infliximab infusion, or any other therapeutic agent targeted at reducing tumor necrosis factor-a (TNF-a).
• •Hypersensitivity to any murine proteins or other component of infliximab for those patients to receive infliximab.
• •Inability to comply with study procedures