Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
University of Chicago
With
Pfizer
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Metastatic or unresectable cancer for which standard treatments do not exist or are no longer effective or cancers where evidence of efficacy of single agent sunitinib or single agent mTOR inhibitor has been demonstrated
Measurable or non-measurable disease.
No prior treatments for 4 weeks before starting study
No ongoing toxicities from previous treatments
18 years or older
Performance status 2 or better
Life expectancy of at least 3 months.
Normal organ and marrow function as defined below:
* No transfusions of packed red blood cells within 1 week of starting treatment. A hemoglobin of 9.0 g/dL or greater is recommended. Patients should not be transfused for protocol participation.
* Leukocytes greater than or equal to 3,000/μL
* Absolute neutrophil count greater than or equal to 1,500/μL
* Platelets greater than or equal to 100,000/μL
* Total bilirubin less than or equal to 1.5 x ULN
* AST and ALT less than or equal to 2.5x ULN (less than or equal to 5x ULN if liver function abnormalities are due to underlying disease)
* Creatinine within normal institutional limits OR
* Creatinine clearance \> 60 mL/min/1.73 m2
* PT or INR within normal institutional limits
* Serum calcium within normal institutional limits
QTc \< 500 msec.
Patients with prior anthracycline exposure or that have received central thoracic radiation must have NYHA class I cardiac function
Must agree to use adequate birth control
Ability to understand and the willingness to sign a written informed consent document.
You may not be if
Prior treatments within 4 weeks (6 weeks for nitrosoureas or mitomycin C) of entering the study or those who have not recovered from adverse events due prior treatments
Current treatment with other investigational agents.
Prior therapy with a VEGFR or mTOR inhibitor
History of allergic reactions attributed to compounds of similar chemical or biologic composition to rapamycin or sunitinib.
QTc prolongation (QTc interval equal to or greater than 500 msec) or other significant ECG abnormalities
Uncontrolled intercurrent illness or psychiatric illness/social situations that would limit compliance with study requirements.
Patients with any of the following conditions are excluded:
* Serious or non-healing wound, ulcer, or bone fracture.
* History of abdominal fistula, gastrointestinal perforation, or intra-abdominal abscess within 28 days of treatment.
* Known active infection
* Major surgery or radiation therapy within 4 weeks of starting the study treatment.
* NCI CTCAE Version 3.0 grade 3 hemorrhage within 4 weeks of starting the study treatment.
* History of CVA or transient ischemic attack within 12 months prior to study entry.
* History of myocardial infarction, cardiac arrhythmia, stable/unstable angina, symptomatic congestive heart failure, or coronary/peripheral artery bypass graft or stenting within 12 months prior to study entry.
* History of pulmonary embolism within the past 12 months.
* Class III or IV heart failure as defined by the NYHA functional classification system
* Ongoing cardiac dysrhythmias
* Poorly controlled hypertension (systolic blood pressure of 140 mmHg or higher or diastolic blood pressure of 90 mmHg or higher)
* Pre-existing thyroid abnormality with thyroid function that cannot be maintained in the normal range with medication
* History of interstitial lung disease
Patients with severe immunodeficient states (as judged by the treating physician)
Pregnancy or breastfeeding.
HIV-positive patients on combination antiretroviral therapy are ineligible because of the potential for interactions with the study drugs
Use of certain medications (as determined by the investigator)
Other severe acute or chronic medical or psychiatric condition or laboratory abnormality that may increase the risk or interfere with the study
Clareo Health | Interaction Study of Rapamycin and Sunitinib in Patients With Advanced Cancers
