Saves the questions and what to expect into your notes, next to the visit they belong to.
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Lead
Vanderbilt University
With
National Center for Research Resources (NCRR)
National Heart, Lung, and Blood Institute (NHLBI)
Patients with chronic OI appear to be hypovolemic with abnormalities in hormones that regulate salt \& water handling. Increases in dietary salt have salutary effects on orthostatic tolerance in a physiological laboratory. The infusion of intravenous saline acutely decreased heart rate in this patient population. Preliminary data from Vanderbilt suggests abnormal salt handling in patients with chronic OI in a few patients. These data need to be confirmed and a better understanding of sodium handling in response to acute salt loads is required in these patients.
Age
18–65
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
Diagnosed with orthostatic intolerance by Vanderbilt Autonomic Dysfunction Center (or healthy control subject)
You may not be if
Overt or acute cause for orthostatic tachycardia
Hypertension (BP\>145/95 or need for anti-hypertensive medications)
