Effects of Etanercept on Nail Psoriasis and Plaque Psoriasis

Inclusion Criteria

• •18 years of age or older
• •Active, stable plaque psoriasis defined by the following criteria:
• •* Body surface area (BSA) ≥ 10 % at screening and baseline
• •* Or, PASI \>10 at screening and baseline
• •* Or, PGA of Psoriasis status of moderate or worse (moderate, marked, or severe) at screening and baseline
• •* Or, DLQI \> 10 at baseline
• •Active fingernail psoriasis defined as target fingernail NAPSI ≥ 2 and overall NAPSI \> 14 - Target nail is defined as the nail with the highest nail score (matrix+bed scores) at baseline. Should more than one fingernail have the same score, the target fingernail will be chosen by the investigator.
• •Failure of at least one systemic psoriasis therapy for nail psoriasis
• •Eligible to receive biologic therapy for psoriasis in accordance to local guidelines