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COMPLETEDNANCT00580294

A Pilot Study of Switching From One Pain Medication to Another (Opioid Rotation)

The purpose of this study is to see if changing from one pain medication like morphine or oxycodone to another pain medication, oxymorphone (OPANA®), will be helpful to patients. This study will exami...

Lead sponsor: Icahn School of Medicine at Mount Sinai•1 U.S. locations•View source on ClinicalTrials.gov

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Sponsors

Lead Sponsor

Icahn School of Medicine at Mount Sinai

Collaborators

Endo Pharmaceuticals

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

Inclusion Criteria

•Age of 18 to no upper limit
•Chronic pain of nociceptive, neuropathic, or mixed origin
•Patients with chronic non cancer pain
•Ongoing chronic opioid treatment with either oral morphine or oxycodone (long term - more than 3 months of at least a total daily opioid dose of 60 mg morphine or of 30 mg oxycodone)
•Pain of moderate intensity (\>4, on the numerical scale 0-10) despite ongoing opioid therapy\>
•Non-pregnant, non-lactating women
•Sufficient language skills to communicate with research staff

Exclusion Criteria

•Clinically significant respiratory, renal, hepatic, or cardiac disease.
•Documented diagnosis of sleep apnea (the study physician may exclude patients who present with clinical features and complaints suggestive of a diagnosis of probable sleep apnea)
•History of illicit drug or alcohol dependence or abuse, abnormal drug taking / seeking behaviors
•Severe depression (\> 26 on the BDI)
•Patients who exhibit a score on the Mini Mental Status Exam (MMSE) of 26 or less. (The range of scores for mild dementia is 21-26 on the MMSE).
•Workman compensation, current or pending medical-legal litigation
•Hypersensitivity to study medication (oxymorphone)

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: February 3, 2016Terms

Trial snapshot

StatusCOMPLETED

PhaseNA

Enrollment12

Start dateNov 2007

Last updatedFeb 3, 2016

Condition

Locations shown

Icahn School of Medcine at Mount Sinai

New York, New York

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: February 3, 2016Data synced to Clareo: July 13, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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