Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
University of Nebraska
The purpose of this study is to determine if a combination of methotrexate and minocycline works better than methotrexate alone in early Rheumatoid Arthritis (RA). Specific aims of this study are:
A. To demonstrate that the combination of minocycline and methotrexate is well tolerated when used in the first year of RA.
B. To compare the efficacy of the combination of minocycline and methotrexate with methotrexate and placebo therapy in early sero-positive RA patients.
Age
19–75
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Age over or equal to 19 years old and less than or equal to 75 years old
Diagnosis of RA as determined by fulfilling 4 of 7 ACR criteria
Positive rheumatoid factor
Duration of disease: greater than six weeks and less than one year
You may not be if
Allergy to tetracycline or methotrexate
Previous DMARD treatment
Doses of oral steroids greater than 7.5 mg/day
Intra-articular injections within the last four weeks
Significant liver or renal disease or active peptic ulcer disease
Patients who are not willing to abstain from alcohol consumption
Women of childbearing potential who are not practicing a successful method of contraception
